TLX1 Gene Summary [Human]
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | TLX1 |
| Official Name | T cell leukemia homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5056] |
| Ensembl ID | ENSG00000107807 |
| Bio databases IDs | |
| Aliases | T cell leukemia homeobox 1, Homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch), homeo box 11 (T-cell lymphoma 3-associated breakpoint) |
| Synonyms | HOX11, RGD1563655, T cell leukaemia homeobox 1, T-cell leukaemia, homeobox 1, T cell leukemia homeobox 1, T-cell leukemia, homeobox 1, TCL3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TLX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- glycine proline rich domain
- octapeptide domain
- protein binding
- glutamine-rich domain
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphatic neoplasia
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- B cell cancer
- B-cell neoplasia
- metastasis
- tumorigenesis
role in cell
- apoptosis
- quantity
- expression in
- proliferation
- development
- colony formation
- abnormal morphology
- number
- differentiation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TLX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organ development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity