GPR139 Gene Summary [Human]
This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | GPR139 |
| Official Name | G protein-coupled receptor 139 [Source:HGNC Symbol;Acc:HGNC:19995] |
| Ensembl ID | ENSG00000180269 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 139 |
| Synonyms | Gm495, GPRg1, G protein-coupled receptor 139, PGR3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR139 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR139 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- attention deficit hyperactivity disorder
- diabetes mellitus
- insomnia
- metabolic syndrome X
- streptococcal pharyngitis
- Huntington disease
- restless legs syndrome
regulated by
- beta-estradiol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR139 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- neuropeptide receptor activity