PLK5 Gene Summary [Human]
Predicted to enable ATP binding activity and protein kinase activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLK5 |
| Official Name | polo like kinase 5 (inactive) [Source:HGNC Symbol;Acc:HGNC:27001] |
| Ensembl ID | ENSG00000185988 |
| Bio databases IDs | |
| Aliases | polo like kinase 5 (inactive) |
| Synonyms | 6330514A18Rik, PLK5P, polo-like kinase 5, polo like kinase 5 (inactive), SgK384ps |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLK5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine/Threonine protein kinases, catalytic domain
- POLO box duplicated region
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Protein kinase domain
- POLO_box
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PLK5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- squamous cell lung cancer
- epithelial neoplasia
- epithelial cancer
- diffuse large B-cell lymphoma
- acute myeloid leukemia
- lung squamous cell carcinoma
- fallopian tube cancer
- ovarian cancer
- Huntington disease
regulated by
- hydrazine
- E1
role in cell
- apoptosis
- proliferation
- development
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLK5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- defense response to tumor cell
- cellular response to growth factor stimulus
- cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- regulation of apoptotic process
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase activity