CYP4Z1 Gene Summary [Human]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
CYP4Z1
Official Name
cytochrome P450 family 4 subfamily Z member 1 [Source:HGNC Symbol;Acc:HGNC:20583]
Ensembl ID
ENSG00000186160
Bio databases IDs NCBI: 199974 Ensembl: ENSG00000186160
Aliases cytochrome P450 family 4 subfamily Z member 1
Synonyms CYP4A20, cytochrome P450 family 4 subfamily Z member 1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYP4Z1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cytochrome P450 (CYP) superfamily
  • Cytochrome P450
  • arachidonic acid 14,15-epoxygenase
  • monooxygenase
  • enzyme

Pathways

Biological processes and signaling networks where the CYP4Z1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • breast carcinoma
  • Parkinson disease
  • chronic obstructive pulmonary disease
  • diabetic nephropathy
regulates
  • ERK1/2
  • arachidonic acid
  • PI3K (complex)
  • TIMP2
  • VEGF
  • lauric acid

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • microsomal fraction
  • membrane fraction
  • Endoplasmic Reticulum
  • Mitochondria
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CYP4Z1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • lauric acid metabolic process
  • arachidonic acid metabolic process

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane

Molecular Function

What the gene product does at the molecular level
  • iron ion binding
  • aromatase activity
  • arachidonic acid 14,15-epoxygenase activity
  • fatty acid in-chain hydroxylase activity
  • heme binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.