DCHS2 Gene Summary [Human]

This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass. [provided by RefSeq, May 2017]

Details

Type
Protein Coding
Official Symbol
DCHS2
Official Name
dachsous cadherin-related 2 [Source:HGNC Symbol;Acc:HGNC:23111]
Ensembl ID
ENSG00000197410
Bio databases IDs NCBI: 54798 Ensembl: ENSG00000197410
Aliases dachsous cadherin-related 2, cadherin-related family member 7
Synonyms CDH27, CDHJ, CDHR7, dachsous cadherin-related 2, EG627094, Gm417, Gm6731, LOC100534287, PCDH23, PCDHJ, RGD1563329
Species
Human, Homo sapiens
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCHS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin repeat-like domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hepatocellular carcinoma
  • liver cancer
  • epithelial cancer
  • major depression
  • overall survival
  • Graves disease
  • Alzheimer disease
  • TCF3-PBX1 fusion positive acute lymphoblastic leukemia
  • progression free survival
  • thyrotoxic periodic paralysis
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DCHS2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • nephron development
  • homophilic cell adhesion
  • condensed mesenchymal cell proliferation

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • calcium ion binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.