MED1 Gene Summary [Human]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MED1 |
| Official Name | mediator complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:9234] |
| Ensembl ID | ENSG00000125686 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 1 |
| Synonyms | ARC205, CRSP1, CRSP200, CRSP205, CRSP210, DRIP205, DRIP230, l11Jus15, Med220, mediator complex subunit 1, PBP, PPARBP, PPARGBP, RB18A, RGD1559552, TRAP220, TRIP-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- PKC phosphorylation site
- LXXLL motif
- transcription co-activator
- RNA recognition motif
- retinoic acid receptor binding
- transcription co-repressor
- transcription cofactor
- transcription factor binding
- chromatin binding
- estrogen receptor binding
- receptor binding domain
- peroxisome proliferator activated receptor binding
- Pka phosphorylation site
- histone acetyltransferase binding
- nuclear receptor domain
- ligand-dependent nuclear receptor interactor
- DNA binding domain
- nucleic acid binding
- ubiquitin protein ligase activity
- vitamin D receptor binding
- protein binding
- thyroid hormone receptor binding
- LBD domain binding
- sequence-specific DNA binding
- Mediator of RNA polymerase II transcription subunit 1
- DNA binding
- binding protein
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the MED1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- allergic rhinitis
- asthma
- hypoplasia
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- growth failure
- lipodystrophy
- pericardial effusion
- refractive error
role in cell
- expression in
- apoptosis
- formation
- quantity
- accumulation in
- differentiation
- binding in
- number
- proliferation
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
- chromatin
- plasma
- interphotoreceptor matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic hemopoiesis
- fat cell differentiation
- lens development in camera-type eye
- positive regulation of erythrocyte differentiation
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- regulation of vitamin D receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- retinal pigment epithelium development
- monocyte differentiation
- peroxisome proliferator activated receptor signaling pathway
- embryonic hindlimb morphogenesis
- mRNA transcription from RNA polymerase II promoter
- positive regulation of keratinocyte differentiation
- regulation of RNA biosynthetic process
- epithelial cell proliferation involved in mammary gland duct elongation
- cell morphogenesis
- brain development
- ventricular trabecula myocardium morphogenesis
- keratinocyte differentiation
- G0 to G1 transition
- protein import into nucleus
- positive regulation of gene expression
- cellular response to epidermal growth factor stimulus
- organ regeneration
- positive regulation of G0 to G1 transition
- protein ubiquitination
- positive regulation of transcription initiation from RNA polymerase II promoter
- mammary gland branching involved in pregnancy
- negative regulation of neuron differentiation
- lactation
- positive regulation of transcription from RNA polymerase II promoter
- embryonic placenta development
- mammary gland branching involved in thelarche
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to thyroid hormone stimulus
- negative regulation of keratinocyte proliferation
- angiogenesis
- liver development
- megakaryocyte development
- thyroid hormone generation
- enucleate erythrocyte development
- hemopoietic stem cell differentiation
- erythrocyte development
- embryonic heart tube development
- thyroid hormone mediated signaling pathway
- positive regulation of interferon-gamma-mediated signaling pathway
- regulation of transcription from RNA polymerase II promoter
- cellular response to steroid hormone stimulus
- androgen biosynthetic process
- intracellular steroid hormone receptor signaling pathway
- negative regulation of apoptotic process
- cellular response to hepatocyte growth factor stimulus
- positive regulation of intracellular estrogen receptor signaling pathway
- positive regulation of hepatocyte proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- ubiquitin ligase complex
- membrane
- mediator complex
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- ligand-dependent nuclear receptor binding
- histone acetyltransferase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin binding
- retinoic acid receptor binding
- peroxisome proliferator activated receptor binding
- transcription coactivator binding
- thyroid hormone receptor binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- LBD domain binding
- transcription corepressor activity
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- estrogen receptor binding