RNF212B Gene Summary [Human]
Predicted to enable SUMO transferase activity. Predicted to be involved in homologous chromosome pairing at meiosis and protein sumoylation. Predicted to be active in synaptonemal complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNF212B |
| Official Name | ring finger protein 212B [Source:HGNC Symbol;Acc:HGNC:20438] |
| Ensembl ID | ENSG00000215277 |
| Bio databases IDs | |
| Aliases | ring finger protein 212B |
| Synonyms | C14orf164, Gm10332, Gm30805, Ring finger protein 212B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF212B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- SlyX
- enzyme
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF212B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reciprocal meiotic recombination
- protein sumoylation
- synapsis
Cellular Component
Where in the cell the gene product is active
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- SUMO ligase activity