TAFA5 Gene Summary [Human]
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | TAFA5 |
| Official Name | TAFA chemokine like family member 5 [Source:HGNC Symbol;Acc:HGNC:21592] |
| Ensembl ID | ENSG00000219438 |
| Bio databases IDs | |
| Aliases | TAFA chemokine like family member 5 |
| Synonyms | FAM19A5, QLLK5208, RGD1562115, TAFA chemokine like family member 5, Tara-5, UNQ5208 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAFA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- receptor agonist activity
- TAFA family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAFA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- negative regulation of vascular wound healing
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- receptor agonist activity
- cytokine activity