ATXN8OS Gene Summary [Human]
This gene is an antisense transcript to the KLHL1 gene (homolog to the Drosophila KELCH gene); it does not itself appear to be protein coding. A TAC/TGC trinucleotide repeat expansion that is incorporated into this gene transcript, but not the KLHL1 transcript, causes spinocerebellar ataxia type 8. Presumably the expansion interferes with normal antisense function of this transcript. [provided by RefSeq, Oct 2008]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | ATXN8OS |
| Official Name | ATXN8 opposite strand lncRNA [Source:HGNC Symbol;Acc:HGNC:10561] |
| Ensembl ID | ENSG00000230223 |
| Bio databases IDs | |
| Aliases | ATXN8 opposite strand lncRNA, non-protein coding RNA 3 |
| Synonyms | ATXN8 opposite strand lncRNA, KLHL1AS, NCRNA00003, SCA8 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- mir-204 (includes others)
disease
- schizophrenia
- Alzheimer disease
- breast cancer
- organismal death
- spinocerebellar ataxia
- Parkinson disease
- streptococcal pharyngitis
- late-onset Parkinson disease
- spinocerebellar ataxia 8
- spinocerebellar ataxia type 6
role in cell
- expression in
- proliferation
- invasion by
- cell viability
- growth
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown