RGS21 Gene Summary [Human]
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
Details
| Type | Protein Coding |
| Official Symbol | RGS21 |
| Official Name | regulator of G protein signaling 21 [Source:HGNC Symbol;Acc:HGNC:26839] |
| Ensembl ID | ENSG00000253148 |
| Bio databases IDs | |
| Aliases | regulator of G protein signaling 21 |
| Synonyms | EG624910, LOC100364404, LOC102551739, regulator of G-protein signaling 21, regulator of G-protein signalling 21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGS21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- enzyme
Pathways
Biological processes and signaling networks where the RGS21 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGS21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- sensory perception of umami taste
- G-protein coupled receptor signaling pathway
- sensory perception of sweet taste
- sensory perception of bitter taste
- transmission of nerve impulse
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTPase activity