KCNJ18 Gene Summary [Human]
This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | KCNJ18 |
| Official Name | potassium inwardly rectifying channel subfamily J member 18 [Source:HGNC Symbol;Acc:HGNC:39080] |
| Ensembl ID | ENSG00000260458 |
| Bio databases IDs | |
| Aliases | potassium inwardly rectifying channel subfamily J member 18 |
| Synonyms | KIR2.6, potassium inwardly rectifying channel subfamily J member 18, TTPP2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNJ18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inward rectifier potassium channel
- Inward rectifier potassium channel C-terminal domain
- Inward rectifier potassium channel transmembrane domain
- protein binding
- Inward rectifier potassium channel N-terminal
- ion channel
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNJ18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- inward rectifier potassium channel activity