Oas1h Gene Summary [Mouse]

Enables double-stranded RNA binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of cytokine production; and regulation of innate immune response. Predicted to be located in mitochondrion and ribosome. Predicted to be active in cytosol; membrane; and nucleoplasm. Predicted to colocalize with cytoplasm. Is expressed in ovary. Human ortholog(s) of this gene implicated in immunodeficiency 100. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Oas1h
Official Name
2'-5' oligoadenylate synthetase 1H [Source:MGI Symbol;Acc:MGI:2180853]
Ensembl ID
ENSMUSG00000001168
Bio databases IDs NCBI: 246729 Ensembl: ENSMUSG00000001168
Aliases 2'-5' oligoadenylate synthetase 1H
Synonyms 2'-5' oligoadenylate synthetase 1D, 2'-5' oligoadenylate synthetase 1E, 2 ' -5 ' oligoadenylate synthetase 1H, LOC100910214, LOC103689988, Oas1c, Oas1d, Oas1e, Oasl6
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oas1h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  • Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
  • double-stranded RNA binding
  • enzyme
  • 2'-5'-oligoadenylate synthetase

Pathways

Biological processes and signaling networks where the Oas1h gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • NFkB (complex)
  • HRAS

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • ribosome
  • Nucleus
  • Mitochondria
  • cytosol
  • nucleoplasm

Gene-Specific Assays for Results You Can Trust

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