Kcnh6 Gene Summary [Mouse]
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in several processes, including potassium ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be active in plasma membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; retina; and skin. Used to study glucose metabolism disease. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnh6 |
| Official Name | potassium voltage-gated channel, subfamily H (eag-related), member 6 [Source:MGI Symbol;Acc:MGI:2684139] |
| Ensembl ID | ENSMUSG00000001901 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, subfamily H (eag-related), member 6 |
| Synonyms | ERG-2, HERG2, Kv11.2, m-erg2, potassium voltage-gated channel, subfamily H (eag-related), member 6, potassium voltage-gated channel subfamily H member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnh6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- inward rectifier potassium channel
- Ion transport protein
- PAS domain S-box
- PAS
- ion channel
- PAS fold
- Cyclic nucleotide-monophosphate binding domain
- Cyclic nucleotide-binding domain
- voltage-gated potassium channel
- binding protein
- PAS domain
- CAP_ED
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnh6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of cardiac muscle cell action potential
- potassium ion transmembrane transport
- regulation of ventricular cardiomyocyte membrane repolarization
- regulation of heart rate by cardiac conduction
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inward rectifier potassium channel activity