Thra Gene Summary [Mouse]
The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Thra |
| Official Name | thyroid hormone receptor alpha [Source:MGI Symbol;Acc:MGI:98742] |
| Ensembl ID | ENSMUSG00000058756 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor alpha |
| Synonyms | 6430529J03Rik, AR7, c-erbA, c-ERBA-1, c-erbA-alpha, c-erbA-α, CHNG6, EAR7, ERBA, ERBA1, ERB-T-1, NR1A1, Rvr, T3R[a], T3Ralpha, T3r α, Thra1, THRalpha, THRalpha1, THRalpha2, Thr α, thyroid hormone receptor alpha, Thyroid hormone receptor α, TRalpha, TR α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- A/B region
- transcription factor binding
- AF-2 transcription activation domain
- chromatin binding
- TATA-binding protein binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- P-box
- ligand-binding domain
- ligand-dependent nuclear receptor
- hormone binding
- DNA binding domain
- nucleic acid binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- single-stranded RNA binding
- DNA binding
- binding protein
- double-stranded DNA binding
- protein homodimerization
- hinge domain
- thyroid hormone receptor binding domain
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
- RNA-binding domain
Pathways
Biological processes and signaling networks where the Thra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myocardial infarction
- congestive heart failure
- heart failure
- metastasis
- obesity
- hepatic steatosis
- dyslipidemia
- hyperlipidemia
- coronary disease
- COVID-19
phenotypes
- abnormal body weight
- abnormal bone structure
- abnormal contextual conditioning behavior
- abnormal embryo size
- abnormal retinal inner nuclear layer morphology
- abnormal tail movements
- decreased exploration in new environment
- decreased mean corpuscular hemoglobin
- decreased startle reflex
- decreased total body fat amount
- decreased total retina thickness
- hyperactivity
- improved glucose tolerance
- increased bone mineral content
- increased bone mineral density
- increased circulating alkaline phosphatase level
- increased lean body mass
- increased startle reflex
- limb grasping
- preweaning lethality incomplete penetrance
- abnormal adipose tissue amount
- abnormal bone mineral content
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal bone remodeling
- abnormal bone strength
- abnormal cerebellum external granule cell layer morphology
- abnormal chondrocyte physiology
- abnormal cochlear outer hair cell morphology
- abnormal compact bone morphology
- abnormal defecation
- abnormal enterocyte morphology
- abnormal enterocyte physiology
- abnormal enterocyte proliferation
- abnormal enzyme/coenzyme activity
- abnormal glucose homeostasis
- abnormal hippocampus morphology
- abnormal hormone level
- abnormal insulin secretion
- abnormal intestinal goblet cell morphology
- abnormal intestinal mucosa morphology
- abnormal joint morphology
- abnormal lean body mass
- abnormal locomotor activation
- abnormal locomotor behavior
- abnormal locomotor coordination
- abnormal long bone diaphysis morphology
- abnormal long bone epiphyseal ossification zone morphology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone metaphysis morphology
- abnormal mitochondrial ATP synthesis coupled electron transport
- abnormal object recognition memory
- abnormal osteoclast physiology
- abnormal pancreatic islet morphology
- abnormal postnatal growth
- abnormal pup retrieval
- abnormal response/metabolism to endogenous compounds
- abnormal small intestine morphology
- abnormal thyroid follicle morphology
- abnormal thyroid gland physiology
- abnormal thyroid-stimulating hormone level
- abnormal total retina thickness
- abnormal trabecular bone morphology
- decreased activity of thyroid gland
- decreased areal bone mineral density
- decreased body length
- decreased body temperature
- decreased body weight
- decreased bone mineral content
- decreased bone mineral density
- decreased bone resorption
- decreased cardiac cell glucose uptake
- decreased circulating insulin-like growth factor I level
- decreased circulating thyroxine level
- decreased circulating triiodothyronine level
- decreased compact bone area
- decreased compact bone thickness
- decreased core body temperature
- decreased food intake
- decreased heart rate
- decreased hemoglobin content
- decreased length of long bones
- decreased litter size
- decreased liver weight
- decreased mean systemic arterial blood pressure
- decreased osteoclast cell number
- decreased small intestinal villus height
- decreased small intestine length
- decreased trabecular bone thickness
- decreased ventricle muscle contractility
- decreased width of hypertrophic chondrocyte zone
- delayed cranial suture closure
- delayed endochondral bone ossification
- delayed hair appearance
- delayed intramembranous bone ossification
- impaired adaptive thermogenesis
- impaired glucose tolerance
- impaired lipolysis
- increased activity of thyroid gland
- increased anxiety-related response
- increased body temperature
- increased body weight
- increased bone mass
- increased bone trabecula number
- increased circulating glucagon level
- increased circulating glucose level
- increased circulating insulin level
- increased circulating leptin level
- increased circulating thyroid-stimulating hormone level
- increased circulating thyroxine level
- increased circulating triiodothyronine level
- increased compact bone thickness
- increased compact bone volume
- increased diameter of long bones
- increased epididymal fat pad weight
- increased glucagon secretion
- increased heart rate
- increased insulin secretion
- increased insulin sensitivity
- increased long bone epiphyseal plate size
- increased thyroid-stimulating hormone level
- increased total body fat amount
- increased trabecular bone thickness
- increased trabecular bone volume
- increased triiodothyronine level
- insulin resistance
- large fontanelles
- obese
- oliguria
- osteosclerosis
- perinatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality complete penetrance
- premature death
- prenatal lethality complete penetrance
- prolonged QRS complex duration
- prolonged QT interval
- prolonged estrous cycle
- reduced female fertility
- reduced fertility
- reduced male fertility
- short femur
- short limbs
- short tail
- short tibia
- short ulna
- small heart
- small pancreatic islets
- thyroid gland hypoplasia
- wide cranial sutures
role in cell
- expression in
- migration
- differentiation
- apoptosis
- phosphorylation in
- proliferation
- production in
- quantity
- activation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- myelin enriched fraction
- nuclear fraction
- Cytoplasm
- perinuclear region
- Mitochondria
- cytosol
- basolateral membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of female receptivity
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- learning or memory
- hormone-mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- response to cold
- regulation of lipid catabolic process
- retinoic acid receptor signaling pathway
- cartilage condensation
- negative regulation of transcription, DNA-dependent
- ossification
- Type I pneumocyte differentiation
- female courtship behavior
- regulation of myeloid cell apoptotic process
- regulation of heart contraction
- thyroid hormone mediated signaling pathway
- regulation of thyroid hormone mediated signaling pathway
- regulation of transcription from RNA polymerase II promoter
- erythrocyte differentiation
- thyroid gland development
- cell differentiation
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
- negative regulation of transcription initiation, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein domain specific binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- thyroid hormone binding
- transcription regulatory region sequence-specific DNA binding
- TBP-class protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity