Cbfa2t3 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; mesenchyme derived from splanchnopleure; retina; and spleen. Orthologous to human CBFA2T3 (CBFA2/RUNX1 partner transcriptional co-repressor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbfa2t3 |
| Official Name | CBFA2/RUNX1 translocation partner 3 [Source:MGI Symbol;Acc:MGI:1338013] |
| Ensembl ID | ENSMUSG00000006362 |
| Bio databases IDs | |
| Aliases | CBFA2/RUNX1 translocation partner 3 |
| Synonyms | A630044F12Rik, AI465270, AW229127, CBFA2/RUNX1 partner transcriptional co-repressor 3, CBFA2/RUNX1 translocation partner 3, CBFA2T3H, ETO-2, MTG16, MTGR2, RUNX1T3, ZMYND4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cbfa2t3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nhr2 domain
- transcription regulator
- NHR2 domain like
- NHR1 homology to TAF
- MYND finger
- nervy homology region domain
- transcription co-repressor
- TAF homology
- chromatin binding
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic lymphocytic leukemia
- neuroticism
- anemia
- insulin-dependent diabetes mellitus
- ulcerative colitis
- androgenic alopecia
- ophthalmic disorder
- colitis
- non-melanoma skin cancer
role in cell
- proliferation
- growth
- expression in
- quantity
- differentiation
- development
- cellular reprogramming
- recruitment in
- synthesis in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular space
- Golgi Apparatus
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cbfa2t3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- transcription, DNA-dependent
- negative regulation of cell proliferation
- negative regulation of glycolysis
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- granulocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Golgi membrane
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity