Qtrt1 Gene Summary [Mouse]
Enables tRNA-guanosine(34) queuine transglycosylase activity. Involved in tRNA-guanine transglycosylation. Located in cytoplasmic side of mitochondrial outer membrane and nucleus. Part of protein-containing complex. Colocalizes with mitochondrion. Is expressed in several structures, including alimentary system; facial bone primordium; nervous system; respiratory system; and urinary system. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Qtrt1 |
| Official Name | queuine tRNA-ribosyltransferase catalytic subunit 1 [Source:MGI Symbol;Acc:MGI:1931441] |
| Ensembl ID | ENSMUSG00000002825 |
| Bio databases IDs | |
| Aliases | queuine tRNA-ribosyltransferase catalytic subunit 1 |
| Synonyms | 2610028E17Rik, FP3235, queuine tRNA-ribosyltransferase catalytic subunit 1, TGT, TGUT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Qtrt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- queuine tRNA-ribosyltransferase
- protein homodimerization
- enzyme
- protein binding
- tRNA-guanine family transglycosylase
- PRK01008
- protein heterodimerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Qtrt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- macromolecular complex
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- metal ion binding
- protein heterodimerization activity
- queuine tRNA-ribosyltransferase activity