Clcnkb Gene Summary [Mouse]
This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKA (geneID:1187). [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | Clcnkb |
| Official Name | chloride channel, voltage-sensitive Kb [Source:MGI Symbol;Acc:MGI:1930643] |
| Ensembl ID | ENSMUSG00000006216 |
| Bio databases IDs | |
| Aliases | chloride channel, voltage-sensitive Kb |
| Synonyms | chloride channel, voltage-sensitive Kb, chloride voltage-gated channel Kb, Clck2, ClC-K2L, Clc-Ka, CLCKB, Clcnk1l, Clcnk2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcnkb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- CBS domain
- Voltage gated chloride channel
- chloride channel
- protein binding
- identical protein binding
- voltage-gated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- magnesium
- chloride
- prostaglandin
regulated by
- EPRS1
disease
- hyperplasia
- growth failure
- hydronephrosis
- polyuria
- hypokalemia
- alkalosis
phenotypes
- abnormal bone structure
- abnormal heart morphology
- abnormal heart shape
- abnormal kidney morphology
- abnormal liver morphology
- abnormal lymph node morphology
- abnormal ovary morphology
- abnormal pancreas morphology
- abnormal skin morphology
- abnormal spleen morphology
- abnormal stomach morphology
- abnormal urinary bladder morphology
- decreased body weight
- decreased circulating alanine transaminase level
- decreased exploration in new environment
- decreased heart weight
- decreased lymphocyte cell number
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular volume
- decreased total body fat amount
- enlarged heart
- enlarged kidney
- enlarged lymph nodes
- enlarged spleen
- enlarged urinary bladder
- improved glucose tolerance
- increased blood urea nitrogen level
- increased circulating alkaline phosphatase level
- increased circulating creatinine level
- increased fasting circulating glucose level
- increased grip strength
- increased heart rate
- increased lean body mass
- increased red blood cell distribution width
- shortened QRS complex duration
- shortened RR interval
- small heart
- small kidney
- abnormal RR interval
- abnormal adipose tissue amount
- abnormal blood urea nitrogen level
- abnormal body length
- abnormal body weight
- abnormal circulating alkaline phosphatase level
- abnormal circulating creatinine level
- abnormal distal convoluted tubule morphology
- abnormal fasting circulating glucose level
- abnormal glucose tolerance
- abnormal heart weight
- abnormal juxtaglomerular apparatus morphology
- abnormal kidney afferent arteriole morphology
- abnormal kidney blood vessel morphology
- abnormal kidney efferent arteriole morphology
- abnormal lean body mass
- abnormal loop of Henle ascending limb thick segment morphology
- abnormal mean corpuscular hemoglobin
- abnormal mean corpuscular volume
- abnormal renal sodium ion transport
- abnormal renal transport
- abnormal urine homeostasis
- alkalemia
- alkalosis
- decreased circulating chloride level
- decreased circulating insulin level
- decreased circulating potassium level
- decreased physiological sensitivity to xenobiotic
- decreased renal glomerular filtration rate
- decreased urine osmolality
- dilated distal convoluted tubules
- hydronephrosis
- hypokalemia
- hypotension
- hypovolemia
- increased circulating renin level
- increased urine chloride ion level
- increased urine magnesium level
- increased urine potassium level
- increased urine prostaglandin level
- increased urine sodium level
- juxtaglomerular cell hyperplasia
- polyuria
- postnatal growth retardation
- premature death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
- Golgi membrane