Clcnkb Gene Summary [Mouse]
This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKA (geneID:1187). [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | Clcnkb |
| Official Name | chloride channel, voltage-sensitive Kb [Source:MGI Symbol;Acc:MGI:1930643] |
| Ensembl ID | ENSMUSG00000006216 |
| Bio databases IDs | |
| Aliases | chloride channel, voltage-sensitive Kb |
| Synonyms | chloride channel, voltage-sensitive Kb, chloride voltage-gated channel Kb, Clck2, ClC-K2L, Clc-Ka, CLCKB, Clcnk1l, Clcnk2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcnkb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- CBS domain
- Voltage gated chloride channel
- chloride channel
- protein binding
- identical protein binding
- voltage-gated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- growth failure
- hydronephrosis
- polyuria
- hypokalemia
- alkalosis
regulated by
- EPRS1
regulates
- magnesium
- chloride
- prostaglandin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
- Golgi membrane