Slc6a18 Gene Summary [Mouse]
Enables neutral L-amino acid:sodium:chloride symporter activity. Involved in neutral amino acid transport and renal amino acid absorption. Acts upstream of or within amino acid transmembrane transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including metanephros. Orthologous to human SLC6A18 (solute carrier family 6 member 18). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a18 |
| Official Name | solute carrier family 6 (neurotransmitter transporter), member 18 [Source:MGI Symbol;Acc:MGI:1336892] |
| Ensembl ID | ENSMUSG00000021612 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 (neurotransmitter transporter), member 18 |
| Synonyms | B0AT3, D630001K16Rik, Rosit, solute carrier family 6 member 18, solute carrier family 6 (neurotransmitter transporter), member 18, Xt2, Xtrp2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc6a18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:chloride symporter
- Sodium:neurotransmitter symporter family
- sodium:amino acid transporter
- protein binding
- Solute carrier families 5 and 6-like; solute binding domain
- amino acid transporter
- transporter
- neutral amino acid transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc6a18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- nitrogen compound transport
- neutral amino acid transport
- sodium ion transmembrane transport
- amino acid transport
- amino acid transmembrane transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- amino acid transmembrane transporter activity