Ldc1 Gene Summary [Mouse]
Predicted to be involved in negative regulation of protein catabolic process; positive regulation of polyamine transmembrane transport; and putrescine biosynthetic process from arginine, via ornithine. Predicted to be active in cytoplasm. Orthologous to human LDC1P (leucine decarboxylase 1, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ldc1 |
| Official Name | leucine decarboxylase 1 [Source:MGI Symbol;Acc:MGI:2685699] |
| Ensembl ID | ENSMUSG00000023120 |
| Bio databases IDs | |
| Aliases | leucine decarboxylase 1 |
| Synonyms | Gm853, leucine decarboxylase 1, RGD1562036 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ldc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
- Pyridoxal-dependent decarboxylase, C-terminal sheet domain
- Pyridoxal-dependent decarboxylase, pyridoxal binding domain
- diaminopimelate decarboxylase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- alloxan-induced diabetic nephropathy
- diabetes mellitus
regulated by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown