Cblif Gene Summary [Mouse]
Enables cargo receptor ligand activity; cobalamin binding activity; and molecular carrier activity. Involved in cobalamin transport. Is active in extracellular space. Is expressed in gut and lung. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cblif |
| Official Name | cobalamin binding intrinsic factor [Source:MGI Symbol;Acc:MGI:1202394] |
| Ensembl ID | ENSMUSG00000024682 |
| Bio databases IDs | |
| Aliases | cobalamin binding intrinsic factor |
| Synonyms | cobalamin binding intrinsic factor, Gif, IF, INF |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cblif often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vitamin binding
- Eukaryotic cobalamin-binding protein
- binding protein
- Domain of unknown function (DUF4430)
- protein binding
- tetrapyrrole binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endosomes
- apical membrane
- microvilli