Sspn Gene Summary [Mouse]
Located in sarcolemma. Is expressed in early conceptus; secondary oocyte; and skin. Orthologous to human SSPN (sarcospan). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sspn |
| Official Name | sarcospan [Source:MGI Symbol;Acc:MGI:1353511] |
| Ensembl ID | ENSMUSG00000030255 |
| Bio databases IDs | |
| Aliases | sarcospan |
| Synonyms | DAGA5, DKFZP434L0272, Gm32675, KRAG, LOC102550089, LOC102641082, NSPN, RGD1559723, SANCOSPAN, sarcospan, SPN1, SPN2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sspn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysine rich domain
- binding protein
- CAAX box
- CD20-like family
- membrane targeting signal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SMO
- TP63
- H1-2
- Dystroglycan
- TP53
- SUPT6H
disease
- atrial fibrillation
- metabolic syndrome X
- COVID-19
- heart failure
- cancer
- epithelial cancer
- autosomal dominant polycystic kidney disease
- renal cancer
- kidney carcinoma
- breast carcinoma
role in cell
- cell viability
- adhesion
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic membrane
- Golgi membrane
- neuromuscular junctions
- sarcolemma
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sspn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- sarcolemma
- dystrophin-associated glycoprotein complex
- transport vesicle
- plasma membrane