Atp4b Gene Summary [Mouse]
Predicted to enable ATPase activator activity and P-type potassium:proton transporter activity. Predicted to contribute to heterocyclic compound binding activity. Predicted to be involved in intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and pH reduction. Predicted to act upstream of or within protein glycosylation and regulation of proton transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of potassium:proton exchanging ATPase complex and sodium:potassium-exchanging ATPase complex. Is expressed in alimentary system; stomach; stomach epithelium; stomach fundus; and stomach mucosa. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; and stomach cancer. Orthologous to human ATP4B (ATPase H+/K+ transporting subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp4b |
| Official Name | ATPase, H+/K+ exchanging, beta polypeptide [Source:MGI Symbol;Acc:MGI:88114] |
| Ensembl ID | ENSMUSG00000031449 |
| Bio databases IDs | |
| Aliases | ATPase, H+/K+ exchanging, beta polypeptide |
| Synonyms | ATP6B, ATPase, H+/K+ exchanging, beta polypeptide, ATPase, H+/K+ exchanging, β polypeptide, ATPase H+/K+ transporting subunit beta, ATPase H+/K+ transporting subunit β, H+/K+-ATPase Beta Subunit, H+/K+-ATPase β Subunit, S76401S1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- H+/K+-exchanging ATPase
- protein binding
- Sodium / potassium ATPase beta chain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- rabeprazole
- omeprazole
- pantoprazole
- tenatoprazole
- AGN 201904
- esomeprazole magnesium
- ilaprazole
- AR-H047108
- lansoprazole
- dexlansoprazole
disease
- non-insulin-dependent diabetes mellitus
- infection
- psoriasis
- cardiovascular disorder
- otitis media with effusion
- coronary thrombosis
- erosive esophagitis
- Helicobacter pylori infection
- hoarseness
- epigastric pain
regulated by
- Immunoglobulin
- KRT8
- rabeprazole
- pantoprazole
- ilaprazole
- AGN 201904
- omeprazole
- AR-H047108
- dexlansoprazole
- esomeprazole magnesium
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular potassium ion homeostasis
- potassium ion transmembrane transport
- cellular sodium ion homeostasis
- cell adhesion
- response to lipopolysaccharide
- pH reduction
- response to organic nitrogen
Cellular Component
Where in the cell the gene product is active
- hydrogen:potassium-exchanging ATPase complex
- sodium:potassium-exchanging ATPase complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen:potassium-exchanging ATPase activity
- ATPase activator activity