Atp4a Gene Summary [Mouse]
Enables P-type potassium:proton transporter activity. Acts upstream of or within pH reduction; regulation of proton transport; and response to xenobiotic stimulus. Located in plasma membrane. Is expressed in body of stomach and stomach epithelium. Orthologous to human ATP4A (ATPase H+/K+ transporting subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Atp4a |
| Official Name | ATPase, H+/K+ exchanging, gastric, alpha polypeptide [Source:MGI Symbol;Acc:MGI:88113] |
| Ensembl ID | ENSMUSG00000005553 |
| Bio databases IDs | |
| Aliases | ATPase, H+/K+ exchanging, gastric, alpha polypeptide |
| Synonyms | ATP6A, ATPase, H+/K+ exchanging, gastric, alpha polypeptide, ATPase, H+/K+ exchanging, gastric, α polypeptide, Atpase, h+/k+ transporting, alpha polypeptide, ATPase H+/K+ transporting subunit alpha, ATPase H+/K+ transporting subunit α, Atpase, h+/k+ transporting, α polypeptide, Gastric H+/K+ ATPase Alpha, Gastric H+/K+ ATPase α, Hka, H+,K+-ATPase, H+/K+ ATPASE, Hkatpc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- metal ion binding
- heavy metal translocating P-type ATPase
- protein binding
- magnesium ion binding
- plasma-membrane proton-efflux P-type ATPase
- E1-E2 ATPase
- copper-(or silver)-translocating P-type ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- plasma-membrane calcium-translocating P-type ATPase
- H+/K+-exchanging ATPase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Cation transporting ATPase, C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsing-remitting multiple sclerosis
- gastroesophageal reflux
- ulcerative gastroesophageal reflux
- erosive esophagitis
- Helicobacter pylori infection
- obstructive lung disease
- endocrine adenoma
- dyspepsia
- nonulcer dyspepsia
- gastrointestinal disturbance
role in cell
- morphology
- abnormal morphology
- quantity
- osmotic fragility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- apical membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular potassium ion homeostasis
- potassium ion transmembrane transport
- ion transmembrane transport
- establishment or maintenance of transmembrane electrochemical gradient
- cellular sodium ion homeostasis
- pH reduction
- response to xenobiotic stimulus
- regulation of proton transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- hydrogen:potassium-exchanging ATPase complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- potassium ion binding
- sodium:potassium-exchanging ATPase activity
- hydrogen:potassium-exchanging ATPase activity