ATP4B Gene Summary [Human]
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ATP4B |
| Official Name | ATPase H+/K+ transporting subunit beta [Source:HGNC Symbol;Acc:HGNC:820] |
| Ensembl ID | ENSG00000186009 |
| Bio databases IDs | |
| Aliases | ATPase H+/K+ transporting subunit beta |
| Synonyms | ATP6B, ATPase, H+/K+ exchanging, beta polypeptide, ATPase, H+/K+ exchanging, β polypeptide, ATPase H+/K+ transporting subunit beta, ATPase H+/K+ transporting subunit β, H+/K+-ATPase Beta Subunit, H+/K+-ATPase β Subunit, S76401S1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- H+/K+-exchanging ATPase
- protein binding
- Sodium / potassium ATPase beta chain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- rabeprazole
- omeprazole
- pantoprazole
- tenatoprazole
- AGN 201904
- esomeprazole magnesium
- ilaprazole
- AR-H047108
- lansoprazole
- dexlansoprazole
disease
- non-insulin-dependent diabetes mellitus
- infection
- psoriasis
- cardiovascular disorder
- otitis media with effusion
- coronary thrombosis
- erosive esophagitis
- Helicobacter pylori infection
- hoarseness
- epigastric pain
regulated by
- Immunoglobulin
- KRT8
- rabeprazole
- pantoprazole
- ilaprazole
- AGN 201904
- omeprazole
- AR-H047108
- dexlansoprazole
- esomeprazole magnesium
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular potassium ion homeostasis
- potassium ion transmembrane transport
- cellular sodium ion homeostasis
- cell adhesion
- response to lipopolysaccharide
- pH reduction
- response to organic nitrogen
Cellular Component
Where in the cell the gene product is active
- hydrogen:potassium-exchanging ATPase complex
- sodium:potassium-exchanging ATPase complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen:potassium-exchanging ATPase activity
- ATPase activator activity