Arhgap39 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in postsynapse organization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; ganglia; gut; nose; and skeletal musculature. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap39 |
| Official Name | Rho GTPase activating protein 39 [Source:MGI Symbol;Acc:MGI:107858] |
| Ensembl ID | ENSMUSG00000033697 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 39 |
| Synonyms | 9530053N22, CrGAP, D15Wsu169e, KIAA1688, PORF-2, Rho GTPase activating protein 39, Vilse |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase activator
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- WW domain
- MyTH4 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- breast cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- attention deficit hyperactivity disorder
- breast carcinoma
regulated by
role in cell
- proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- glutaminergic synapse
- postsynaptic region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity