Clcnka Gene Summary [Mouse]
This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKB (geneID:1188). Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | Clcnka |
| Official Name | chloride channel, voltage-sensitive Ka [Source:MGI Symbol;Acc:MGI:1329026] |
| Ensembl ID | ENSMUSG00000033770 |
| Bio databases IDs | |
| Aliases | chloride channel, voltage-sensitive Ka |
| Synonyms | chloride channel, voltage-sensitive Ka, chloride voltage-gated channel Ka, CLC-K1, Clcnk1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcnka often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- CBS domain
- Voltage gated chloride channel
- chloride channel
- protein binding
- identical protein binding
- voltage-gated ion channel
- voltage-gated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polyuria
regulates
- chloride
- PNPLA6
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane