Ppargc1b Gene Summary [Mouse]
Predicted to enable AF-2 domain binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Involved in several processes, including bone trabecula formation; positive regulation of bone resorption; and positive regulation of metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in brown fat; central nervous system; heart; sensory organ; and tibialis anterior. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppargc1b |
| Official Name | peroxisome proliferative activated receptor, gamma, coactivator 1 beta [Source:MGI Symbol;Acc:MGI:2444934] |
| Ensembl ID | ENSMUSG00000033871 |
| Bio databases IDs | |
| Aliases | peroxisome proliferative activated receptor, gamma, coactivator 1 beta |
| Synonyms | 4631412G21Rik, ERRL1, LOC153346, PERC, peroxisome proliferative activated receptor, gamma, coactivator 1 beta, peroxisome proliferative activated receptor, γ, coactivator 1 β, PGC1B, PGC-1beta, PGC-1(beta), PGC-1beta/ERRL1, PGC-1(β), Pgc1 β, PPARGC-1-beta, PPARGC-1-β, PPARG coactivator 1 beta, PPARG coactivator 1 β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppargc1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- leucine rich domain
- LXXLL motif
- transcription co-activator
- AF-2 domain binding
- RNA recognition motif
- transcription cofactor
- protein binding
- estrogen receptor binding
Pathways
Biological processes and signaling networks where the Ppargc1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- epithelial cancer
- squamous cell cancer
- epithelial basal cell carcinoma
- obesity
- Huntington disease
- sunburn
- androgenic alopecia
- macrovesicular hepatic steatosis
- cutaneous melanoma
role in cell
- function
- expression in
- quantity
- proliferation
- apoptosis
- synthesis in
- size
- activity
- differentiation
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppargc1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phosphorylation
- transcription from mitochondrial promoter
- actin filament organization
- regulation of transcription, DNA-dependent
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- bone trabecula formation
- negative regulation of transcription, DNA-dependent
- positive regulation of osteoclast differentiation
- ossification
- positive regulation of bone resorption
- cellular response to reactive oxygen species
- intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mediator complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- RNA binding
- AF-2 domain binding
- ligand-dependent nuclear receptor transcription coactivator activity
- estrogen receptor binding
- transcription factor binding