Nfkb2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Involved in non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including follicular dendritic cell differentiation; germinal center formation; and spleen development. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; musculature; and thymus primordium. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkb2 |
| Official Name | nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [Source:MGI Symbol;Acc:MGI:1099800] |
| Ensembl ID | ENSMUSG00000025225 |
| Bio databases IDs | |
| Aliases | nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 |
| Synonyms | CVID10, H2TF1, lyt, LYT-10, NF-kappaB2, NF-kappaB2 p100, NF-kappaB2 p52, NFKB, NF-κB2, NF-κB2 p100, NF-κB2 p52, nuclear factor kappa B subunit 2, nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100, nuclear factor of κ light polypeptide gene enhancer in B cells 2, p49/p100, nuclear factor κ B subunit 2, p100, p49, p49/p100, p50B, p50 NF KAPPA B HOMOLOG, p50 NF κ B HOMOLOG, p52, P80HT, RGD1307189 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfkb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- glycine rich domain
- transcription regulator
- Ankyrin repeats (many copies)
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- alpha helix
- transcription activation domain
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- C-terminal death domain
- double-stranded DNA binding
- N-terminal sub-domain of the Rel homology domain (RHD)
- Death Domain Superfamily of protein-protein interaction domains
- transcription factor activity
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Nfkb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- B Cell Activating Factor Signaling
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- GNRH Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-9 Signaling
- Induction of Apoptosis by HIV1
- Inflammasome pathway
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- LXR/RXR Activation
- Maturity Onset Diabetes of Young (MODY) Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- PEDF Signaling
- Rac Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- cancer
- growth failure
- hyperplasia
- weight loss
- glioma
- glioma formation
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
role in cell
- phosphorylation in
- activation in
- expression in
- apoptosis
- transcription in
- proliferation
- production in
- migration
- differentiation
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfkb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- regulation of transcription, DNA-dependent
- spleen development
- NIK/NF-kappaB cascade
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- follicular dendritic cell differentiation
- germinal center formation
- inflammatory response
- rhythmic process
- innate immune response
- extracellular matrix organization
- cellular response to stress
- response to lipopolysaccharide
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Bcl3/NF-kappaB2 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity