Nfkb2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Involved in non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including follicular dendritic cell differentiation; germinal center formation; and spleen development. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; musculature; and thymus primordium. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkb2 |
| Official Name | nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [Source:MGI Symbol;Acc:MGI:1099800] |
| Ensembl ID | ENSMUSG00000025225 |
| Bio databases IDs | |
| Aliases | nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 |
| Synonyms | CVID10, H2TF1, lyt, LYT-10, NF-kappaB2, NF-kappaB2 p100, NF-kappaB2 p52, NFKB, NF-κB2, NF-κB2 p100, NF-κB2 p52, nuclear factor kappa B subunit 2, nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100, nuclear factor of κ light polypeptide gene enhancer in B cells 2, p49/p100, nuclear factor κ B subunit 2, p100, p49, p49/p100, p50B, p50 NF KAPPA B HOMOLOG, p50 NF κ B HOMOLOG, p52, P80HT, RGD1307189 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfkb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- glycine rich domain
- transcription regulator
- Ankyrin repeats (many copies)
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- alpha helix
- transcription activation domain
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- C-terminal death domain
- double-stranded DNA binding
- N-terminal sub-domain of the Rel homology domain (RHD)
- Death Domain Superfamily of protein-protein interaction domains
- transcription factor activity
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Nfkb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- Adrenomedullin signaling pathway
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Androgen Signaling
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- Apelin Endothelial Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Apoptosis Signaling
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- Atherosclerosis Signaling
- Autophagy
- B Cell Activating Factor Signaling
- B Cell Receptor Signaling
- BMP signaling pathway
- Breast Cancer Regulation by Stathmin1
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- LXR/RXR Activation
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- cancer
- growth failure
- hyperplasia
- weight loss
- glioma
- glioma formation
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
phenotypes
- abnormal B cell differentiation
- abnormal CD4-positive T cell differentiation
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal Peyer's patch T cell area morphology
- abnormal Peyer's patch follicle morphology
- abnormal Peyer's patch germinal center morphology
- abnormal Peyer's patch morphology
- abnormal T cell differentiation
- abnormal T cell number
- abnormal T cell subpopulation ratio
- abnormal bone marrow morphology
- abnormal class switch recombination
- abnormal cytokine secretion
- abnormal definitive hematopoiesis
- abnormal food intake
- abnormal gamma-delta T cell morphology
- abnormal immunoglobulin level
- abnormal lymph node B cell domain morphology
- abnormal lymph node cortex morphology
- abnormal lymph node morphology
- abnormal lymphocyte cell number
- abnormal mesenteric lymph node morphology
- abnormal metallophilic macrophage morphology
- abnormal myeloid dendritic cell morphology
- abnormal osteoclast differentiation
- abnormal peripheral lymph node morphology
- abnormal plasma cell differentiation
- abnormal spleen B cell follicle morphology
- abnormal spleen follicular dendritic cell network
- abnormal spleen marginal zone macrophage morphology
- abnormal spleen marginal zone morphology
- abnormal spleen morphology
- abnormal spleen periarteriolar lymphoid sheath morphology
- abnormal spleen primary B follicle morphology
- abnormal spleen secondary B follicle morphology
- abnormal spleen white pulp morphology
- abnormal stomach cardiac region morphology
- abnormal thymus cell ratio
- abnormal thymus corticomedullary boundary morphology
- abnormal thymus physiology
- abnormal thymus size
- abnormal trabecular bone morphology
- absent Peyer's patches
- absent axillary lymph nodes
- absent brachial lymph nodes
- absent cervical lymph nodes
- absent inguinal lymph nodes
- absent lymph node germinal center
- absent mesenteric lymph nodes
- absent spleen germinal center
- absent spleen marginal zone
- anemia
- autoimmune response
- decreased B cell number
- decreased B cell proliferation
- decreased B-2 B cell number
- decreased CD4-positive alpha beta T cell number
- decreased IgA level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG2b level
- decreased IgG3 level
- decreased IgM level
- decreased NK cell number
- decreased body size
- decreased body weight
- decreased dendritic cell number
- decreased double-positive T cell number
- decreased effector memory CD8-positive alpha-beta T cell number
- decreased fibroblast cell migration
- decreased fibroblast chemotaxis
- decreased follicular B cell number
- decreased gamma-delta T cell number
- decreased immunoglobulin level
- decreased litter size
- decreased lymph node number
- decreased marginal zone B cell number
- decreased mature B cell number
- decreased myeloid dendritic cell number
- decreased spleen weight
- decreased transitional stage B cell number
- decreased transitional stage T2 B cell number
- disheveled coat
- enlarged lymph nodes
- enlarged spleen
- extramedullary hematopoiesis
- hunched posture
- increased B cell proliferation
- increased B-1 B cell number
- increased B-1a cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased CD8-positive naive alpha-beta T cell number
- increased IgG2a level
- increased IgM level
- increased T cell number
- increased T cell proliferation
- increased double-negative T cell number
- increased double-positive T cell number
- increased granulocyte number
- increased interleukin-10 secretion
- increased interleukin-2 secretion
- increased interleukin-4 secretion
- increased lymphocyte cell number
- increased plasmacytoid dendritic cell number
- increased sensitivity to induced morbidity/mortality
- increased spleen red pulp amount
- increased spleen weight
- increased splenocyte apoptosis
- increased susceptibility to parasitic infection
- increased transitional stage B cell number
- increased tumor necrosis factor secretion
- intermingled spleen red and white pulp
- liver inflammation
- lung inflammation
- osteopetrosis
- premature death
- reduced fertility
- small Peyer's patches
- small stomach
- spleen atrophy
- spleen hypoplasia
- stomach epithelial hyperplasia
- thymus atrophy
- weight loss
role in cell
- phosphorylation in
- activation in
- expression in
- apoptosis
- transcription in
- proliferation
- production in
- migration
- differentiation
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfkb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- regulation of transcription, DNA-dependent
- spleen development
- NIK/NF-kappaB cascade
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- follicular dendritic cell differentiation
- germinal center formation
- inflammatory response
- rhythmic process
- innate immune response
- extracellular matrix organization
- cellular response to stress
- response to lipopolysaccharide
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Bcl3/NF-kappaB2 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity