Mrgprd Gene Summary [Mouse]
Enables G protein-coupled peptide receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure. Predicted to be active in plasma membrane. Is expressed in genitourinary system; nervous system; and skin. Used to study dilated cardiomyopathy. Orthologous to human MRGPRD (MAS related GPR family member D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrgprd |
| Official Name | MAS-related GPR, member D [Source:MGI Symbol;Acc:MGI:3033142] |
| Ensembl ID | ENSMUSG00000051207 |
| Bio databases IDs | |
| Aliases | MAS-related GPR, member D |
| Synonyms | Gm499, MAS related GPR family member D, MAS-related GPR, member D, Mgrd, MRGD, TGR7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrgprd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- beta-alanine
disease
- cancer
- colon cancer
- pruritus
- cold allodynia
- mechanical hypersensitivity
regulated by
- beta-alanine
regulates
- cyclic AMP
- Ca2+
- KCNQ2/3
role in cell
- sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- nerve ending
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrgprd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity