Foxi3 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including otic placode development; parathyroid gland development; and pharyngeal system development. Is active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; exocrine system; integumental system; and sensory organ. Used to study Goldenhar syndrome. Orthologous to human FOXI3 (forkhead box I3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxi3 |
| Official Name | forkhead box I3 [Source:MGI Symbol;Acc:MGI:3511278] |
| Ensembl ID | ENSMUSG00000055874 |
| Bio databases IDs | |
| Aliases | forkhead box I3 |
| Synonyms | CFM2, forkhead box I3, LOC669126, LOC730270, RGD1561816 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxi3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- activin (family)
- BMP4
disease
- Goldenhar syndrome
- craniofacial microsomia type 1
- craniofacial microsomia type 2
- cranioschisis
phenotypes
- abnormal Meckel's cartilage morphology
- abnormal facial morphology
- abnormal geniculate ganglion morphology
- abnormal mandible morphology
- abnormal maxilla morphology
- abnormal middle ear morphology
- abnormal nervous system development
- abnormal otic placode morphology
- abnormal palatine bone morphology
- abnormal pharyngeal pouch morphology
- abnormal temporal bone squamous part morphology
- abnormal trigeminal ganglion morphology
- abnormal vestibulocochlear ganglion morphology
- absent incus
- absent inner ear
- absent malleus
- absent mouth
- absent outer ear
- absent pharyngeal arches
- absent stapes
- absent tympanic ring
- absent vibrissae
- absent zygomatic bone
- cranioschisis
- embryonic lethality during organogenesis incomplete penetrance
- increased cranial neural crest cell apoptosis
- increased embryonic tissue cell apoptosis
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- small face
- syngnathia
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxi3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermal cell fate specification
- hair follicle development
- cell differentiation
- odontogenesis of dentin-containing tooth
- anatomical structure morphogenesis
- pharyngeal system development
- parathyroid gland development
- regulation of transcription from RNA polymerase II promoter
- thymus development
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity