Bap1 Gene Summary [Mouse]
Enables chromatin DNA binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; hematopoietic stem cell homeostasis; and myeloid cell differentiation. Acts upstream of or within macrophage homeostasis; regulation of cytokine production involved in inflammatory response; and regulation of inflammatory response. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of PR-DUB complex. Predicted to be active in cytoplasm. Is expressed in several structures, including cerebral cortex; decidua; gonad; mammary gland; and trophectoderm. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma; extrahepatic bile duct adenocarcinoma; and uveal melanoma. Orthologous to human BAP1 (BRCA1 associated deubiquitinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bap1 |
| Official Name | Brca1 associated protein 1 [Source:MGI Symbol;Acc:MGI:1206586] |
| Ensembl ID | ENSMUSG00000021901 |
| Bio databases IDs | |
| Aliases | Brca1 associated protein 1 |
| Synonyms | 2300006C11Rik, BRCA1 associated deubiquitinase 1, Brca1 associated protein 1, HUCEP-13, hucep-6, KURIS, mKIAA0272, TPDS1, Ubiquitin Carboxy-terminal Hydrolase, UBM2, UCHL2, uch-x4, UVM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin carboxyl-terminal hydrolases
- conserved domain
- peptidase
- nuclear localization sequence
- ubiquitin-specific protease
- chromatin binding
- enzyme
- protein binding
- ubiquitin C-terminal hydrolase domain
- cysteine peptidase C12
- DNA binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Bap1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- cutaneous melanoma
- nasopharyngeal cancer
- malignant pleural mesothelioma
- organismal death
- liver cancer
- lung squamous cell carcinoma
role in cell
- expression in
- necrosis
- proliferation
- cell death
- apoptosis
- quantity
- degradation in
- phosphorylation in
- growth
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- monoubiquitinated protein deubiquitination
- negative regulation of cell proliferation
- regulation of cytokine production involved in inflammatory response
- mitotic cell cycle
- erythrocyte maturation
- chromatin remodeling
- leukocyte proliferation
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- regulation of cell cycle
- neutrophil differentiation
- protein deubiquitination
- thrombocyte differentiation
- ubiquitin-dependent protein catabolic process
- tissue homeostasis
- neuron homeostasis
- regulation of cell growth
- nucleate erythrocyte differentiation
- regulation of inflammatory response
- gene expression
- common myeloid progenitor cell proliferation
- myeloid cell apoptotic process
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- PR-DUB complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- chromatin DNA binding
- protein binding
- chromatin binding
- peptidase activity