Ddx39a Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; RNA helicase activity; and identical protein binding activity. Predicted to be involved in mRNA export from nucleus and mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to colocalize with cytoplasm. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; integumental system; and nervous system. Orthologous to human DDX39A (DExD-box helicase 39A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx39a |
| Official Name | DEAD box helicase 39a [Source:MGI Symbol;Acc:MGI:1915528] |
| Ensembl ID | ENSMUSG00000005481 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 39a |
| Synonyms | 2610307C23Rik, BAT1, BAT1L, DDX39, DDXL, DEAD box helicase 39a, DEAD-box protein 39, DExD-box helicase 39A, URH49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx39a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- identical protein binding
- Helicase conserved C-terminal domain
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- liver cancer
- colon carcinoma
- colon epithelial cancer
- Waldenström macroglobulinemia
- colon cancer
- epidermal hyperplasia
- psoriasis
- lung cancer
role in cell
- differentiation
- replication in
- colony formation by
- splicing by
- proliferation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx39a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA export from nucleus
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- RNA binding
- protein binding
- RNA helicase activity
- mRNA binding