Gfral Gene Summary [Mouse]
Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in several processes, including GDF15-GFRAL signaling pathway; reduction of food intake in response to dietary excess; and response to metformin. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Located in plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Gfral |
| Official Name | GDNF family receptor alpha like [Source:MGI Symbol;Acc:MGI:3607786] |
| Ensembl ID | ENSMUSG00000059383 |
| Bio databases IDs | |
| Aliases | GDNF family receptor alpha like |
| Synonyms | bA360D14.1, C6orf144, GDNF family receptor alpha like, GDNF family receptor α like, GRAL, RGD1565220, UNQ9356 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gfral often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glial cell line-derived neurotrophic factor receptor
- receptor tyrosine kinase binding
- protein binding
- transmembrane receptor
- GDNF/GAS1 domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- actin cytoskeleton
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gfral gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of appetite
- stress-activated protein kinase signaling cascade
- nervous system development
- positive regulation of MAPK cascade
- reduction of food intake in response to dietary excess
- positive regulation of protein kinase B signaling cascade
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- external side of plasma membrane
- actin cytoskeleton
- receptor complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- glial cell-derived neurotrophic factor receptor activity
- receptor tyrosine kinase binding
- hormone activity