Rnf123 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein maturation; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm. Is expressed in liver. Orthologous to human RNF123 (ring finger protein 123). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf123 |
| Official Name | ring finger protein 123 [Source:MGI Symbol;Acc:MGI:2148796] |
| Ensembl ID | ENSMUSG00000041528 |
| Bio databases IDs | |
| Aliases | ring finger protein 123 |
| Synonyms | FP1477, KPC1, ring finger protein 123 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf123 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinase regulatory loop binding domain
- SPRY domain
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- HP1 binding domain
- enzyme
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf123 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- protein maturation
- proteolysis involved in cellular protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- metal ion binding