Nfx1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase activity. Acts upstream of or within negative regulation of MHC class II biosynthetic process and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; integumental system; male reproductive system; and urinary system. Orthologous to human NFX1 (nuclear transcription factor, X-box binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfx1 |
| Official Name | nuclear transcription factor, X-box binding 1 [Source:MGI Symbol;Acc:MGI:1921414] |
| Ensembl ID | ENSMUSG00000028423 |
| Bio databases IDs | |
| Aliases | nuclear transcription factor, X-box binding 1 |
| Synonyms | 1300017N15Rik, 3000003M19Rik, NFX.1, NFX2, nuclear transcription factor, X-box binding 1, TEG-42, TEX42 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- R3H
- nucleic acid binding
- NF-X1 type zinc finger
- R3H domain
- double-stranded DNA binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin protein ligase activity
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- acute myeloid leukemia
- liver cancer
- epithelial cancer
- Hutchinson-Gilford progeria syndrome
regulated by
- HPV-16 E6/E6-AP
- NFX1
- E6
- macrophages
- CD3 (complex)
- GnRH analog
role in cell
- expression in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- transcription from RNA polymerase II promoter
- negative regulation of MHC class II biosynthetic process
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity