Clec4a4 Gene Summary [Mouse]
Enables carbohydrate derivative binding activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid dendritic cell antigen processing and presentation. Predicted to be active in external side of plasma membrane. Is expressed in ductus deferens; epididymis; and prostate gland. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec4a4 |
| Official Name | C-type lectin domain family 4, member a4 [Source:MGI Symbol;Acc:MGI:3624119] |
| Ensembl ID | ENSMUSG00000059639 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 4, member a4 |
| Synonyms | Clec4a2, C-type lectin domain family 4, member A2, C-type lectin domain family 4, member a4, Dcir2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec4a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- calcium ion binding
- Lectin C-type domain
- carbohydrate binding
- transmembrane receptor
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- TRIM26
- curdlan
phenotypes
- decreased grip strength
- decreased neutrophil cell number
- hydrometra
- small superior vagus ganglion
- abnormal grip strength
- abnormal heart morphology
- abnormal neutrophil cell number
- abnormal seminal vesicle morphology
- enlarged heart
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane