Arf2 Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including adrenal gland; brain; cranium; genitourinary system; and nasal septum. Orthologous to human ARF2P (ARF GTPase 2, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arf2 |
| Official Name | ADP-ribosylation factor 2 [Source:MGI Symbol;Acc:MGI:99595] |
| Ensembl ID | ENSMUSG00000062421 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor 2 |
| Synonyms | ADP ribosylation factor, ADP-ribosylation factor 2, ARF GTPase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- GTP binding
- ADP-ribosylation factor family
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Arf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- abnormal bone structure
- abnormal coat/hair pigmentation
- decreased body length
- decreased bone mineral content
- decreased bone mineral density
- decreased exploration in new environment
- decreased lean body mass
- increased hematocrit
- increased total body fat amount
- abnormal body length
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal lean body mass
- abnormal sleep behavior
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus