Gga1 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Involved in Golgi to plasma membrane transport and protein localization to ciliary membrane. Acts upstream of or within positive regulation of protein catabolic process. Predicted to be located in Golgi apparatus; early endosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in trans-Golgi network. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and white fat. Orthologous to human GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gga1 |
| Official Name | golgi associated, gamma adaptin ear containing, ARF binding protein 1 [Source:MGI Symbol;Acc:MGI:2146207] |
| Ensembl ID | ENSMUSG00000033128 |
| Bio databases IDs | |
| Aliases | golgi associated, gamma adaptin ear containing, ARF binding protein 1 |
| Synonyms | 4930406E12Rik, golgi associated, gamma adaptin ear containing, ARF binding protein 1, golgi associated, γ adaptin ear containing, ARF binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gga1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- N-terminal extension of GAT domain
- GAE domain
- Adaptin C-terminal domain
- enzyme binding
- protein binding
- proline rich domain
- Domain present in VPS-27, Hrs and STAM
- ear domain
- GGA homology domain
- hinge domain
- VHS, ENTH and ANTH domain superfamily
- GAT domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alkalinization
- Alzheimer disease
role in cell
- growth
- number
- apoptosis
- morphology
- trapping in
- motility
- confinement in
- molecular cleavage in
- dissociation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- endosomes
- Golgi Apparatus
- trans Golgi network
- endosomal membrane
- nucleoplasm
- perinuclear space
- early endosomes
- peripheral vesicles
- Golgi cisternae
- clathrin-coated vesicles
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gga1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- protein catabolic process
- Golgi to plasma membrane transport
- protein localization
- Golgi to plasma membrane protein transport
- positive regulation of protein catabolic process
- intracellular protein transport
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- trans-Golgi network
- early endosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- endosome membrane
- Golgi apparatus
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- phosphatidylinositol binding
- small GTPase binding