Cfhr4 Gene Summary [Mouse]
Enables complement component C3b binding activity and heparin binding activity. Predicted to be involved in complement activation; proteolysis; and regulation of complement activation, alternative pathway. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfhr4 |
| Official Name | complement factor H-related 4 [Source:MGI Symbol;Acc:MGI:3646434] |
| Ensembl ID | ENSMUSG00000070594 |
| Bio databases IDs | |
| Aliases | complement factor H-related 4 |
| Synonyms | Cfhrc, complement factor H-related 4, Complement factor H-related protein C, EG214403, FHR-C, Gm4788 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfhr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- binding protein
- protein binding
- Sushi repeat (SCR repeat)
- heparin binding
- identical protein binding
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- Staphylococcus aureus pneumonia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space