Reg3b Gene Summary [Mouse]
Predicted to enable several functions, including hormone activity; identical protein binding activity; and peptidoglycan binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Acts upstream of or within response to bacterium. Located in collagen-containing extracellular matrix. Is expressed in central nervous system; dorsal root ganglion; hypoglossal nerve; and intestine. Orthologous to several human genes including REG3A (regenerating family member 3 alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Reg3b |
| Official Name | regenerating islet-derived 3 beta [Source:MGI Symbol;Acc:MGI:97478] |
| Ensembl ID | ENSMUSG00000071356 |
| Bio databases IDs | |
| Aliases | regenerating islet-derived 3 beta |
| Synonyms | HIP, Pap, PAP1, Pap I, regenerating family member 3 beta, regenerating family member 3 β, regenerating islet-derived 3 beta, regenerating islet-derived 3 β, REG-III |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Reg3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- peptidoglycan binding
- hormone
- carbohydrate binding
- identical protein binding
- growth factor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- dextran sodium sulfate-induced colitis
- thermal hyperalgesia
- mechanical hyperalgesia
- intraepithelial neoplasia
role in cell
- quantity
- necrosis
- proliferation
- migration
- survival
- activation
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- apical compartment
- zymogen granules