Nrg1

phenotypes

• abnormal PNS synaptic transmission
• abnormal atrioventricular cushion morphology
• abnormal cardiovascular system physiology
• abnormal cranial ganglia morphology
• abnormal cranial nerve morphology
• abnormal dorsal root ganglion morphology
• abnormal endplate potential
• abnormal excitatory postsynaptic currents
• abnormal glossopharyngeal nerve morphology
• abnormal heart morphology
• abnormal heart ventricle morphology
• abnormal hypoglossal nerve morphology
• abnormal intercostal muscle morphology
• abnormal iris morphology
• abnormal locomotor coordination
• abnormal mammary gland growth during pregnancy
• abnormal mandibular nerve branching
• abnormal mandibular nerve innervation pattern
• abnormal miniature endplate potential
• abnormal motor neuron innervation pattern
• abnormal myelination
• abnormal myocardium layer morphology
• abnormal nerve conduction
• abnormal neural crest cell migration
• abnormal neuromuscular synapse morphology
• abnormal petrosal ganglion morphology
• abnormal phrenic nerve morphology
• abnormal prepulse inhibition
• abnormal sensory neuron innervation pattern
• abnormal spinal nerve morphology
• abnormal superior vagus ganglion morphology
• abnormal sympathetic ganglion morphology
• abnormal trigeminal ganglion morphology
• abnormal trigeminal nerve morphology
• abnormal vagus nerve morphology
• abnormal ventral spinal root morphology
• absent Schwann cells
• absent mandibular nerve
• absent oligodendrocytes
• absent trabeculae carneae
• absent trigeminal nerve
• centrally nucleated skeletal muscle fibers
• cyanosis
• decreased Schwann cell number
• decreased Schwann cell precursor number
• decreased cardiac muscle contractility
• decreased cardiac output
• decreased heart rate
• decreased heart weight
• decreased left ventricle systolic pressure
• decreased motor neuron number
• decreased muscle spindle number
• decreased radial glial cell number
• decreased sensory neuron number
• decreased ventricle muscle contractility
• defasiculated phrenic nerve
• dilated heart ventricle
• embryonic growth arrest
• embryonic lethality during organogenesis complete penetrance
• enhanced long term potentiation
• enlarged heart
• enlarged pericardium
• failure of atrioventricular cushion closure
• hyperactivity
• increased sensitivity to xenobiotic induced morbidity/mortality
• irregular heartbeat
• limp posture
• mydriasis
• neonatal lethality complete penetrance
• no spontaneous movement
• poor circulation
• preweaning lethality complete penetrance
• preweaning lethality incomplete penetrance
• respiratory failure
• small dorsal root ganglion
• small nodose ganglion
• small petrosal ganglion
• thin diaphragm muscle
• thin ventricular wall
• trabecula carnea hypoplasia
• unresponsive to tactile stimuli
• weight loss