Zbtb24 Gene Summary [Rat]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human ZBTB24 (zinc finger and BTB domain containing 24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb24 |
| Official Name | zinc finger and BTB domain containing 24 [Source:RGD Symbol;Acc:1306951] |
| Ensembl ID | ENSRNOG00000000308 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 24 |
| Synonyms | BIF1, Bif1a, Bsg1, ICF2, PATZ2, zinc finger and BTB domain containing 24, ZNF450 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zbtb24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Zinc-finger double domain
- BTB/POZ domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- immunodeficiency-centromeric instability-facial anomalies syndrome type 2
- tumorigenesis
regulates
role in cell
- migration
- differentiation
- autophagy by
- pladienolide B sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zbtb24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hemopoietic progenitor cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding