Vgll2 Gene Summary [Rat]
Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and skeletal muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human VGLL2 (vestigial like family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vgll2 |
| Official Name | vestigial-like family member 2 [Source:RGD Symbol;Acc:1311903] |
| Ensembl ID | ENSRNOG00000000405 |
| Bio databases IDs | |
| Aliases | vestigial-like family member 2 |
| Synonyms | C130057C21Rik, vestigial-like family member 2, VGL2, VITO-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vgll2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Short repeats in human TONDU, fly vestigial and other proteins
- transcription regulator
- Vestigial/Tondu family
- transcription co-activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vgll2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle tissue development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity