Tspear Gene Summary [Rat]
Predicted to be involved in regulation of Notch signaling pathway; signal transduction; and tooth mineralization. Predicted to act upstream of or within Notch signaling pathway; hair cycle process; and sensory perception of sound. Predicted to be located in cell surface; ciliary membrane; and stereocilium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 98; ectodermal dysplasia 14; and tooth agenesis. Orthologous to human TSPEAR (thrombospondin type laminin G domain and EAR repeats). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspear |
| Official Name | thrombospondin-type laminin G domain and EAR repeats [Source:RGD Symbol;Acc:1563108] |
| Ensembl ID | ENSRNOG00000001219 |
| Bio databases IDs | |
| Aliases | thrombospondin-type laminin G domain and EAR repeats |
| Synonyms | C21orf29, C330046G03Rik, DFNB98, ECTD14, ORF65, RGD1563108, STHAG10, thrombospondin-type laminin G domain and EAR repeats, Tnep1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tspear often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LamG
- EPTP domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- colorectal cancer
- selective tooth agenesis type 10
- suicide attempt
- familial nonsyndromic hearing impairment
- hair/tooth type ectodermal dysplasia 14 with or without hypohidrosis
- hair/tooth type ectodermal dysplasia type 14 without hypohidrosis
- hereditary disorder
- organismal death
- autosomal recessive deafness type 98
- male pattern hair loss
regulated by
role in cell
- proliferation
- invasion by
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cilia
- cell surface
- stereocilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tspear gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- Notch signaling pathway
- signal transduction
- regulation of Notch signaling pathway
- hair cycle process
- tooth mineralization
Cellular Component
Where in the cell the gene product is active
- cilium membrane
- stereocilium
- extracellular region
- cell surface