Lias Gene Summary [Rat]
Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process and protein lipoylation. Predicted to act upstream of or within several processes, including neural tube closure; response to lipopolysaccharide; and response to oxidative stress. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lias |
| Official Name | lipoic acid synthetase [Source:RGD Symbol;Acc:1307270] |
| Ensembl ID | ENSRNOG00000002759 |
| Bio databases IDs | |
| Aliases | lipoic acid synthetase |
| Synonyms | 2900022L22RIK, 4933425M12Rik, 7a5ex, HGCLAS, HUSSY-01, LAS, LIP1, lipoic acid synthetase, lip-syn, LS, PDHLD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lias often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipoyl synthase
- N-terminal domain of lipoyl synthase of Radical_SAM family
- Radical_SAM
- lipoate synthase
- Radical SAM superfamily
- PRK12928
- enzyme
- Elongator protein 3, MiaB family, Radical SAM
Pathways
Biological processes and signaling networks where the Lias gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- deficiency of pyruvate dehydrogenase lipoic acid synthetase
- bladder exstrophy
- breast cancer
- Leigh syndrome
- insulin-dependent diabetes mellitus
regulates
- lipoic acid
role in cell
- apoptosis
- survival
- ceralasertib resistance
- berzosertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lias gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- inflammatory response
- neural tube closure
- response to lipopolysaccharide
- lipoate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- lipoate synthase activity
- 4 iron, 4 sulfur cluster binding