Cftr Gene Summary [Rat]
Predicted to enable several functions, including 14-3-3 protein binding activity; ATP hydrolysis activity; and PDZ domain binding activity. Involved in several processes, including bicarbonate transport; cellular response to anoxia; and regulation of cell development. Located in several cellular components, including basolateral plasma membrane; early endosome; and microvillus. Used to study congenital bilateral absence of vas deferens; cystic fibrosis; dental enamel hypoplasia; duodenal ulcer; and gastric ulcer. Biomarker of autosomal recessive polycystic kidney disease; cholestasis; and salpingitis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cftr |
| Official Name | CF transmembrane conductance regulator [Source:RGD Symbol;Acc:2332] |
| Ensembl ID | ENSRNOG00000055103 |
| Bio databases IDs | |
| Aliases | CF transmembrane conductance regulator |
| Synonyms | ABC35, ABCC7, CF, CF transmembrane conductance regulator, CFTR/MRP, cystic fibrosis transmembrane conductance regulator, dJ760C5.1, MRP7, RGD1561193, TNR-CFTR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cftr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proposed F420-0 ABC transporter, ATP-binding protein
- regulatory domain
- phosphonate ABC transporter, ATP-binding protein
- ATP binding
- channel-conductance-controlling ATPase
- pore domain
- nitrate transport ATP-binding subunits C and D
- ATPase
- chloride transporter
- ion channel
- heme ABC exporter, ATP-binding protein CcmA
- bicarbonate transporter
- Ran binding domain
- nucleotide-binding domain
- LPS export ABC transporter ATP-binding protein
- thiol reductant ABC exporter, CydC subunit
- gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit
- chloride channel
- energy-coupling factor transporter ATPase
- nucleotide binding domain 1
- chaperone binding
- multi drug resistance-associated protein (MRP)
- nucleotide binding fold domain
- nickel import ATP-binding protein NikE
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- enzyme binding
- chloride channel regulator
- protein binding
- chloride channel inhibitor activity
- inorganic anion transporter
- cell division ATP-binding protein FtsE
- ABC transporter transmembrane region
- PDZ-domain binding
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- dileucine internalization motif
- Cystic fibrosis TM conductance regulator (CFTR), regulator domain
- cobalt transport protein ATP-binding subunit
- binding protein
- cystic fibrosis transmembrane conductor regulator (CFTR)
- cytosolic tail domain
- ABC transporter
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Cftr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- esophageal adenocarcinoma
- infection
- cystic fibrosis
- coronary artery disease
- cholestasis
- cancer
- pulmonary disease
- CFTR-related disorder
- CFTR deltaF508 heterozygous mutation positive CFTR R352Q mutation positive cystic fibrosis
regulated by
- tetradecanoylphorbol acetate
- carbamylcholine
- adenosine triphosphate
- lipopolysaccharide
- taurine
- chenodeoxycholic acid
- tetrachlorodibenzodioxin
- Na+
- Ca2+
- aflatoxin B1
role in cell
- expression in
- proliferation
- molecular cleavage in
- phosphorylation in
- accumulation in
- apoptosis
- quantity
- activation
- production in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- cytosol
- apical cytoplasm
- endoplasmic reticulum membrane
- apical membrane
- basolateral membrane
- lateral plasma membrane
- Golgi membrane
- lysosome membrane
- endosomal membrane
- recycling endosomes
- early endosomes
- membrane rafts
- detergent insoluble microdomains
- brush border
- microvilli
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cftr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transepithelial water transport
- transmembrane transport
- cholesterol biosynthetic process
- amelogenesis
- positive regulation of exocytosis
- sperm capacitation
- intracellular pH elevation
- multicellular organismal water homeostasis
- positive regulation of enamel mineralization
- vesicle docking involved in exocytosis
- cellular response to cAMP
- membrane hyperpolarization
- establishment of localization in cell
- cholesterol transport
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- bicarbonate transport
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- lysosomal membrane
- cell surface
- endoplasmic reticulum membrane
- early endosome membrane
- chloride channel complex
- nucleus
- early endosome
- clathrin-coated endocytic vesicle membrane
- cytoplasm
- membrane
- Golgi-associated vesicle membrane
- cytosol
- macromolecular complex
- endosome membrane
- recycling endosome
- recycling endosome membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- chloride channel inhibitor activity
- ATPase activity, coupled to transmembrane movement of substances
- channel-conductance-controlling ATPase activity
- chloride channel activity
- anion transmembrane-transporting ATPase activity
- chloride channel regulator activity
- ATP binding
- protein binding
- chaperone binding
- PDZ domain binding
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- isomerase activity
- enzyme binding