Degs1 Gene Summary [Rat]
Predicted to enable retinol isomerase activity and sphingolipid delta-4 desaturase activity. Predicted to be involved in ceramide biosynthetic process and myelin maintenance. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 18. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Degs1 |
| Official Name | delta(4)-desaturase, sphingolipid 1 [Source:RGD Symbol;Acc:70917] |
| Ensembl ID | ENSRNOG00000003223 |
| Bio databases IDs | |
| Aliases | delta(4)-desaturase, sphingolipid 1 |
| Synonyms | Degs, delta(4)-desaturase, sphingolipid 1, δ(4)-desaturase, sphingolipid 1 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Degs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sphingolipid delta-4 desaturase
- Cis-trans isomerase
- Membrane-FADS-like
- Fatty acid desaturase
- retinol isomerase
- enzyme
- Sphingolipid Delta4-desaturase (DES)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria