Capn8 Gene Summary [Rat]
Predicted to enable calcium-dependent cysteine-type endopeptidase activity and identical protein binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within calcium-dependent self proteolysis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human CAPN8 (calpain 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capn8 |
| Official Name | calpain 8 [Source:RGD Symbol;Acc:620085] |
| Ensembl ID | ENSRNOG00000003468 |
| Bio databases IDs | |
| Aliases | calpain 8 |
| Synonyms | calpain 8, CL-2', Cls4, nCL-2 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Capn8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The penta-EF hand (PEF) family
- Calpain family cysteine protease
- calpain
- peptidase
- EFh
- Calpain_III
- CysPc
- identical protein binding
Pathways
Biological processes and signaling networks where the Capn8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- miR-132-3p (and other miRNAs w/seed AACAGUC)
- miR-382-5p (miRNAs w/seed AAGUUGU)
- miR-293-5p (and other miRNAs w/seed CUCAAAC)
disease
- polycystic kidney disease
regulated by
- olanzapine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown