Parp2 Gene Summary [Rat]
Predicted to enable several functions, including pentosyltransferase activity; poly-ADP-D-ribose binding activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Involved in hippocampal neuron apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; and response to oxygen-glucose deprivation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleolus and site of DNA damage. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Parp2 |
| Official Name | poly (ADP-ribose) polymerase 2 [Source:RGD Symbol;Acc:1310568] |
| Ensembl ID | ENSRNOG00000008892 |
| Bio databases IDs | |
| Aliases | poly (ADP-ribose) polymerase 2 |
| Synonyms | ADPRT-2, ADPRTL2, ADPRTL3, ARTD2, Aspartl2, LOC120096960, mPARP-2, pADPRT-2, poly (ADP-ribose) polymerase 2, poly (ADP-ribose) polymerase family, member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Parp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA binding domain
- catalytic domain
- NAD ADP-ribosyltransferase
- Poly(ADP-ribose) polymerase, regulatory domain
- Poly(ADP-ribose) polymerase catalytic domain
- chromatin binding
- enzyme
- protein binding
- WGR domain
- ADP_ribosyl
- binding protein
- damaged DNA binding
- pentosyltransferase
Pathways
Biological processes and signaling networks where the Parp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- cancer
- breast carcinoma
- bilateral invasive breast cancer
- multifocal breast cancer
- non-metastatic breast cancer
- liver cholangiocarcinoma
- metastatic intrahepatic cholangiocarcinoma
- breast cancer
- metastatic breast cancer
role in cell
- activation in
- growth
- production in
- expression in
- cell viability
- size
- quantity
- cell cycle progression
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Parp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- base-excision repair
- DNA ADP-ribosylation
- extrinsic apoptotic signaling pathway
- decidualization
- protein poly-ADP-ribosylation
- positive regulation of cell growth involved in cardiac muscle cell development
- protein auto-ADP-ribosylation
- response to DNA damage stimulus
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- poly-ADP-D-ribose binding
- nucleotidyltransferase activity
- protein binding
- nucleosome binding
- chromatin binding
- damaged DNA binding
- NAD+ ADP-ribosyltransferase activity