Akr1b8

Enables NADP binding activity; alcohol dehydrogenase (NADP+) activity; and retinal binding activity. Involved in polyol metabolic process; retinal metabolic process; and retinol metabolic process. Predicted to be located in extracellular region and lysosome. Predicted to be active in cytosol and mitochondrion. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akr1b8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Akr1b8 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.